People who have had COVID-19 more than once are two or three times more likely to have a range of serious health problems than those who have only had it once, the first major study on the subject said Thursday.

Multiple infections have surged as the pandemic rumbles on and the virus mutates into new strains, but the long-term health effects of reinfection have not been clear.

The U.S. researchers said their new study published in the Nature Medicine journal was the first to look at how reinfection increases the risk of health problems from acute cases as well as long COVID.

The researchers analyzed the anonymous medical records of 5.8 million people in the U.S. Department of Veterans Affairs’ national health care database.

More than 443,000 had tested positive for COVID-19 at least once between March 1, 2020, and April this year.

Nearly 41,000 of that group had COVID more than once. More than 93% had a total of two infections, while 6% had three, and nearly 1% had four.

The other 5.3 million never contracted COVID-19.

When the researchers compared the health outcomes of the different groups, they found that “people who got reinfected have an increased risk of all sorts of adverse health problems,” Ziyad Al-Aly, an epidemiologist at Washington University in St. Louis and the study’s senior author, told AFP.

People with repeat infections were twice as likely to die prematurely and three times more likely to be hospitalized with illness than those who had not been reinfected, the study found.

Heart and lung problems were more than three times more common for people who had been reinfected.

Reinfection also contributes to brain conditions, kidney disease and diabetes, the study said.

And the risk of such problems could increase with each infection, it suggested.

Al-Aly warned that this means that continuous reinfections “would likely elevate the burden of disease in the population.”

Epidemiologist recommends masks

Ahead of a feared COVID-19 spike during the holiday season, he called on people to wear masks to protect themselves.

He also urged authorities to do more to stop the disease from circulating.

“The reason reinfection is happening is that our current vaccine strategy does not block transmission,” he said.

“I think reinfections will continue to happen until we have vaccines that block transmission, offer more durable protection, and are variant proof,” he said.

‘Worrisome’ findings

The authors said the limitations of the study included that most of the veteran participants were older white males.

When the study was released as a preprint in June, U.S. expert Eric Topol described the findings as “worrisome.”

In a Substack post, Topol pointed out that reinfections became “much more common” after April — when the study’s timeframe ended — because of new, more transmissible omicron variants.
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